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KMID : 0603820110170040355
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 4 p.355 ~ p.361
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Evaluation of Urinary Antigen Test for Rapid Diagnosis of Streptococcus pneumoniae in Community-Acquired Pneumonia Patients
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Yu Mi-Young
Kim In-Sik
Kang Sang-Sun
Cha Beong-Hun
Hyun Sung-Hee
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Abstract
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We evaluated the performance of the NOW Streptococcus pneumoniae urinary antigen test, standard culture and polymerase chain reaction for detecting S. pneumoniae. The urinary antigen test of pneumonia patients represented sensitivity at 72% and specificity at 79%. The results of PCR were targeting for autolysin (lytA), pneumolysin (ply), and spn9828. The lytA sensitivity and specificity stood at 56% and 87% respectively while ply sensitivity reported 83% and specificity was 47%, sensitivity and specificity of spn9828 stood at 83% and 73% respectively. The results of urinary antigen test and three genes were all statistically meaningful within P＜0.05. When the urinary antigen test of S. pneumoniae was positive, the three kinds of genes were also likely to be positive. According to the result of urinary antigen test, the results of PCR presented a meaningful difference (P＜0.05). Especially, the urinary antigen test of S. pneumoniae was likely to be positive (P＜0.05) when more than two genes were positive in PCR results.
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KEYWORD
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Pneumonia, Streptococcus pneumoniae, Urinary antigen, lytA, ply, spn9828
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